Protein Flexibility and Stability: Thermophiles Know Best
نویسندگان
چکیده
منابع مشابه
Modeling backbone flexibility improves protein stability estimation.
In designing mutagenesis experiments, it is often crucial to know how certain mutations will affect the structure and thermodynamic stability of the protein. Here, we present a methodology, Eris, to efficiently and accurately compute the stability changes of proteins upon mutations using our protein-modeling suite, Medusa. We evaluate the stability changes upon mutations for 595 mutants from fi...
متن کاملCommentary: the people know best.
Based Participatory Research for Health. San Francisco: Jossey-Bass, 2003, pp. 332–43. 62 Jones J. Bad Blood: The Tuskegee Syphilis Experiment. New York: Free Press, 1993. 63 Moreno JD. Lessons learned a half-century of experimenting on humans. Humanist 1999;59:9–15. 64 Thompson SJ, Gifford SM, Thorpe L. The social and cultural context of risk and prevention: food and physical activity in an ur...
متن کاملQuantitative Stability / Flexibility Relationships
The figure shows that the DCM when applied to the helix-coil transition, and solved using the exact transfer matrix method, is able to fit to experimental data well. The system has some characteristics as cold denaturation even in a helix-system, but the transition is too shallow to be a strong signal of cold denaturation. Nevertheless, the DCM is able to fit to the experimental data with less ...
متن کاملThe Genomics of Disulfide Bonding and Protein Stabilization in Thermophiles
Thermophilic organisms flourish in varied high-temperature environmental niches that are deadly to other organisms. Recently, genomic evidence has implicated a critical role for disulfide bonds in the structural stabilization of intracellular proteins from certain of these organisms, contrary to the conventional view that structural disulfide bonds are exclusively extracellular. Here both compu...
متن کاملThermophiles and thermophilic enzymes
Thermophiles chapter http://lasp.colorado.edu/education/journalists/ yellow_stone/Articles/CH4.PDF This book chapter describes thermophile biology and ecology. It also points out that thermophiles are very diverse phylogenetically. Microbial world: Thermophilic microorganisms http://www.biology.ed.ac.uk/research/groups/jdeacon/ microbes/thermo.htm This page of the Microbial World series is no l...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.1507